Use of a Digital Memory Prosthetic to Support Autobiographical Memory in Down Syndrome

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Down syndrome is a chromosomal abnormality associated with significant deficits across multiple cognitive domains, including a disproportionate deficit in hippocampally-dependent memory. In other words, individuals with Down syndrome may have a particular difficulty remembering specific details from past events. One way this manifests itself is in overgeneral autobiographical memory, or a tendency to remember the general gist of an event or cluster of events, rather than a single, isolated event. This overgeneral memory makes it difficult for individuals with Down syndrome to access their past, can interfere with attempts to becoming more independent, and increases anxiety and depression. In the current VIRTUAL study, the investigators test whether a new digital memory prosthetic-HippoCamera-can enhance specific autobiographical memory in individuals with Down syndrome. In HippoCamera, users are asked to record and replay events from their daily lives. This replay is curated by a research-based algorithm in HippoCamera that optimizes consolidation of these events over time and has been shown to enhance memory specificity in other populations with memory impairments, particularly those that stem from hippocampal disfunction. It is, therefore, likely that similar enhancements in autobiographical memory specificity will be identified in individuals with Down syndrome, highlighting the benefits of this applications in this population.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 15
Maximum Age: 35
Healthy Volunteers: f
View:

• Diagnosis of Down syndrome

• Daily access to a smart phone

• The ability to create and replay memories using HippoCamera with limited support from a guardian

• Informed consent obtained from parent or guardian (or participant, if legally independent)

• Informed verbal assent obtained from participant

• Ability to comprehend instructions, denoted by parent/guardian acknowledgment

• English as a primary written and spoken language

• Normal or corrected-to-normal vision and hearing

• All races/ethnicities and socio-economic statuses

Locations
United States
Massachusetts
Boston College ONLINE STUDY
RECRUITING
Chestnut Hill
Contact Information
Primary
Jaclyn Ford, PhD
jaclyn.ford@bc.edu
617-312-4735
Backup
Lauren Voso, BS
(617) 552-6949
Time Frame
Start Date: 2025-06-01
Estimated Completion Date: 2026-07-31
Participants
Target number of participants: 40
Treatments
Experimental: Immediate intervention
During the first 12 weeks following enrollment, the Immediate Intervention group will engage in daily practice with the HippoCamera app. HippoCamera is a smartphone application that allows participants to record and replay important events in their daily lives. Based on principles from psychology and neuroscience, engaging in this daily practice may increase focus on memory-orientated practices in participants.
Other: Delayed Intervention
During the first 12 weeks following enrollment, the Delayed Intervention group will serve as a control, receiving no intervention. After the initial 12 weeks, they will be entered into daily engagement with the HippoCamera app.
Related Therapeutic Areas
Sponsors
Collaborators: Massachusetts General Hospital, University of Colorado, Denver
Leads: Boston College

This content was sourced from clinicaltrials.gov